689 Silver released from wound dressings damage skin fibroblasts and keratinocytes and ex vivo skin
نویسندگان
چکیده
منابع مشابه
Silver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing.
With advances in nanotechnology, pure silver has been recently engineered into nanometer-sized particles (diameter <100 nm) for use in the treatment of wounds. In conjunction with other studies, we previously demonstrated that the topical application of silver nanoparticles (AgNPs) can promote wound healing through the modulation of cytokines. Nonetheless, the question as to whether AgNPs can a...
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Background: Extensive full-thickness burns require replacement of both epidermis and dermis. In designing skin replacements, the goal has been to re-create this model and make a product which has both essential components. Methods: In the present study, we developed procedures for establishing confluent, stratified layers of cultured human keratinocytes on the surface of modified collagen-chito...
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Nicotinamide (vitamin B3) protects from ultraviolet (UV) radiation-induced carcinogenesis in mice and from UV-induced immunosuppression in mice and humans. Recent double-blinded randomized controlled Phase 2 studies in heavily sun-damaged individuals have shown that oral nicotinamide significantly reduces premalignant actinic keratoses, and may reduce new non-melanoma skin cancers. Nicotinamide...
متن کاملEffects of Wound Dressings on Skin Properties
The treatment of chronic wounds, burns and scars is not easy to solve, because the most suitable dressing for wound care depends not only on the type of wound but also on the stage of the healing process. Wound dressing have been employed to speed up the healing process in acute and chronic wounds by keeping healing tissues moist and increasing superficial wound epithelialization [1,2]. Apart o...
متن کاملSilver-pig skin nanocomposites and mesenchymal stem cells: suitable antibiofilm cellular dressings for wound healing
BACKGROUND Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wound...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.07.366